Substance Use

Fentanyl: What Is a Lethal Dosage?

doctor holding baggie of fentanyl

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Fentanyl Addiction, Overdose & Treatment Options

Hardly a week goes by that you do not hear about a celebrity or someone in your community who has died from an accidental overdose involving fentanyl. 

While fentanyl is a synthetic opioid prescribed as a painkiller, many people with opiate addiction take a dangerous combination of prescription and illegal drugs. Even the tiniest trace of a powerful drug like fentanyl can be lethal.

Learn everything you need to know about this potentially deadly painkiller as we answer the commonly asked question, “What is a lethal dose of fentanyl?”

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What Is Fentanyl?

Fentanyl is a synthetic opioid developed in the 1960s and used as a painkiller to treat moderate to severe pain. It is legally manufactured and distributed in the United States, where it belongs to the list of prescription opioids that are prescribed to patients who have had surgery or those suffering from chronic pain who have a tolerance to other opioids (i.e., need high or more frequent amounts to feel the effect).

Fentanyl was initially developed to treat cancer patients and applied to the skin as a patch called the fentanyl extended-release transdermal system.

Now, in addition to the transdermal patch, fentanyl is also prescribed as a:

  • Lozenge
  • Pill
  • Liquid

According to the United States Drug Enforcement Administration (DEA) and Center for Disease Control and Prevention (CDC), this narcotic is a controlled substance similar to other opioids, except it is 50 times more potent than heroin and 80–100 times more powerful than morphine. 

Because of its potency, this prescription drug is commonly diverted (stolen and sold illegally) for misuse and abuse (1).

Brand Names for Fentanyl:

  • Abstral (sublingual tablets)
  • Actiq (“lollipops”)
  • Duragesic (transdermal patches)
  • Fentora (effervescent buccal tablets)
  • Lazanda (nasal spray) 
  • Onsolis (buccal soluble film)
  • Sublimaze (injection)
  • Subsys (sublingual spray)

What Is a Lethal Dose of Fentanyl?

Fentanyl is often abused by addicts who obtain it on the street or illegally. Based on lab results, two out of five seized counterfeit pills contain lethal doses, which the DEA defines as milligrams of fentanyl (4).

However, the different forms of lab-created fentanyl and its analogs, along with it being often combined with other illicit drugs, make it very difficult to determine the potentially lethal dose. Fentanyl also affects individuals differently, so what might be fatal for one person might not be for another. Simply put, any use of fentanyl is potentially deadly (3).

When you seek help from Zinnia Health, we offer a customized plan developed to help you decide what makes sense for your needs and life. Learn about the different levels of care for substance abuse recovery and reach out to us if you have any questions.

Effects of Fentanyl Abuse

Fentanyl, morphine, heroin, and many other opiates work similarly. These types of drugs bind to receptors in the brain that control pain and emotions. That is why opioids make one feel more relaxed and joyful.

Unlike other drugs, fentanyl is unique because it binds and acts quickly. It also requires a much smaller dose than heroin or morphine. For this reason, fentanyl is a far more dangerous substance, especially when one develops a tolerance and dependency on it, and the risk of overdose is substantially high.

After taking opioids many times, the brain adapts to the drug, diminishing its sensitivity and making it hard to feel pleasure from anything besides the drug. When people become addicted, drug-seeking and drug use take over their lives.

They may feel any or all of the following effects:

  • Extreme high
  • Relaxation
  • Slow breathing 
  • Low blood pressure
  • Dizziness
  • Sedation
  • Nausea
  • Vomiting
  • Urinary retention
  • Constipation
  • Constricted pupils
  • Confusion

Substance use disorders are treatable, with addiction recovery success rates showing much promise (2). However, it is crucial to have a support system to improve your chances of recovery. If you are ready to start your recovery journey, contact us to get started.

Fentanyl Misuse and Abuse

The prescription forms of fentanyl contain small, diluted amounts of the drug. When you hear about people overdosing, those cases often involve an illegal form of fentanyl. Fentanyl abuse first appeared in the 1970s and has been on the rise due to its euphoric (feelings of intense pleasure) effects.

In 2019, more than 36,000 American individuals died from opioids, representing a 15% increase in deaths from 2018 to 2019. The illegal form of fentanyl is created in discreet labs. You will typically find illicit fentanyl sold on the street as:

  • Powder
  • Pills
  • Drops on blotter paper
  • Liquid in eyedroppers
  • Nasal sprays

The counterfeit pill form is frequently made to look like other prescription medications.

It may be mixed with other common street drugs, including cocaine and heroin. The DEA seized more than 9.6 million fake pills laced with fentanyl in 2021, a 430% increase from 2019.

Common street names for fentanyl include:

  • Apace
  • Captain Cody
  • China Girl
  • China Town
  • China White
  • Dance Fever
  • Goodfella
  • Great Bear
  • He-Man
  • Hillbilly Heroin
  • King Ivory
  • Murder 8
  • Oxycat
  • Percs
  • Poison
  • Tango & Cash

Carfentanil is one of many fentanyl analogs, which are drugs manufactured to imitate the effects of other drugs. These drugs have a similar makeup as fentanyl but may not appear in drug tests. The potency of drug analogs varies from less than to greater than fentanyl.

Carfentanil, in particular, is believed to be 10,000 times stronger than fentanyl. In fact, there was a 540% increase in overdose deaths by fentanyl analogs between 2013 and 2016.

Drug dealers often sell fentanyl mixed with methamphetamine, heroin, cocaine, and other drugs. Fentanyl is very potent in small amounts, so it is cheaper to make to enhance the effect of other drugs. Unfortunately, many people who buy drugs on the street may unknowingly get a mixture containing lethal doses of fentanyl.

This opioid crisis has led to widespread public health concerns on both mainstream and social media.

The abuse of painkillers is prevalent, but there are ways to overcome addiction. At Zinnia Health, we understand what families go through when dealing with the recovery process, which is why we offer programs to support the family along with the individual seeking addiction treatment.

Signs of Fentanyl Overdose

People who use fentanyl can experience an overdose, which occurs when a drug causes severe and life-threatening symptoms. Typically, this particular drug overdose will impair a person’s breathing. When the brain does not get enough oxygen, one can go into a coma and suffer from brain damage.

The effects of fentanyl on the brain also slow down the function of other major organs, including the heart, kidneys, and lungs, as well as a person’s motor function.

Potent doses of fentanyl cause a user to experience several dangerous side effects beyond the initial euphoric feelings. When three symptoms are present at the same time, such as coma, small pupils, and difficulty breathing, overdose is very likely. Immediate medical care must be administered to keep that person from suffering from lasting complications and death.

Other dangerous side effects that can lead to death include:

  • Stupor
  • Cold, clammy skin
  • Cyanosis (blue skin)
  • Seizures
  • Respiratory failure

How To Treat a Fentanyl Overdose

If caught early enough and before it reaches the final life-threatening stage, fentanyl overdose can be treated. Naloxone is an effective medication against fentanyl and other opioids if given immediately.

It binds to the opioid receptors in the brain so that the effects of fentanyl are blocked. The solution can be injected with a needle.

The brand names Narcan and Kloxxado are also naloxone but used as a nasal spray. Because fentanyl is one of the most potent opioids, naloxone may have to be given multiple times to treat the opioid overdose fully.

If you suspect someone is overdosing on fentanyl, you can take the following actions:

  1. Call 911 immediately
  2. Roll the person on their side to prevent choking if they vomit
  3. Monitor the person’s breathing and avoid giving any fluids
  4. If the person is not breathing, perform cardiopulmonary resuscitation (CPR)
  5. Administer naloxone if trained to do so

In some states, naloxone is available from legitimate drug markets and pharmacies without needing a prescription. Having naloxone available can be handy if you or a family member abuse fentanyl and suffer from an overdose.

When an overdose is suspected, it is always crucial to contact 911 for emergency medical attention right away, as time is of the essence. This is especially true because a single dose of naloxone might not be enough if someone overdoses on fentanyl. Once medical professionals administer treatment, patients are usually monitored for a couple of hours to make sure their breathing remains normal.

Fentanyl Addiction and Withdrawal Symptoms

Because fentanyl is often mixed with other drugs, it poses more significant risks that can harm the body. In addition, it can cause one to become more dependent on the drug.

Over time, one will find that their brain and body will want and require more fentanyl. When the body is without certain levels of the drug, it can go into withdrawal.

Withdrawal symptoms often feel like the flu and may include:

  • Irritability or sadness
  • Anxiety
  • Insomnia
  • Fever and sweating
  • Chills and goosebumps
  • Runny nose
  • Muscle aches
  • Nausea and vomiting
  • Diarrhea and cramping

A user typically experiences fentanyl withdrawal symptoms within about 12 hours. Within several days, users will find that their symptoms reach a peak and start to diminish over a week. It is possible to have minor effects for a few continued weeks.

The extent of withdrawal symptoms will depend on how much fentanyl was taken, how frequently it was used, and what other drugs were taken with it. The following factors also influence withdrawal symptoms:

  • Taking more doses than prescribed
  • Frequently using fentanyl more than intended
  • Mixing fentanyl with multiple drugs
  • Using another patient’s prescription
  • Abusing illegally produced fentanyl

Not only can fentanyl and other opiates be addictive, but they also can be lethal. This is especially true when mixing heroin, cocaine, meth, and/or fentanyl together.

It is also very dangerous to buy street drugs because you never know if fentanyl might be mixed into them. Even a small dose of fentanyl can cause serious side effects, including coma and death. One pill can kill.

If you or a loved one is struggling with opioid or fentanyl addiction, help is available. You can learn more about our drug and alcohol addiction treatment process, which is always customized to meet your individual needs. If you are suffering from drug addiction, the professional team at Zinnia Health can help.

Zinnia Health offers a wide range of treatment programs and resources to help those suffering from opiate addiction and other substance abuse disorders. To learn how we can help, you can reach us online or call our 24/7 helpline at (855) 430-9439.


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