Substance Use

What Are M365 White Oval Pills?

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What Are M365 White Oval Pills?

White oval pills with “M365” stamped on one side and a division line on the other are a generic prescription medication also known as hydrocodone bitartrate pills.

Hydrocodone bitartrates are a narcotic analgesic that contains hydrocodone and acetaminophen, similar to name brands such as Norco and Vicodin. Physicians prescribe M365 for the treatment of moderately severe pain – usually post-operatively. Unfortunately, due to its inclusion of the drug hydrocodone, m365 is highly addictive.

Too much of this painkiller too often can lead to addiction and unintentional overdose.

If you have found these pills and your loved one doesn’t have pain to manage, they may have an addiction to hydrocodone. People with this addiction sometimes take m365 to “feel good” despite not being in pain. Addiction can cause embarrassment and shame, so they might be reluctant to share this information with you.

If you suspect your loved one has a drug addiction, call one of our addiction specialists at (855) 430-9439 to find out how we can help. Zinnia Health offers dignified treatment for opioid addiction in our private facilities nationwide. Call today to find out how.

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What Does M365 Contain?

M365 pills contain 5mg of hydrocodone and 325mg to 500mg of acetaminophen. Although both ingredients are effective in managing pain individually, combining the two is more effective for post-surgical pain relief and severe back pain. M365 is also better at managing pain caused by cancer and serious injuries.

Combined, the ingredients in M365 provide pain relief; individually, they offer additional benefits, such as suppressing coughs and reducing fevers. A typical M365 pill relieves pain at a dose of 2.5mg to 10mg every 4 to 6 hours as needed.


Acetaminophen or paracetamol is a non-opioid analgesic (pain reliever) and antipyretic (fever reducer) prescription drug used to manage pain and fever. Although experts aren’t sure how acetaminophen works, they agreed to classify it as a non-steroidal anti-inflammatory drug (NSAID) due to its ability to inhibit cyclooxygenase (COX) pathways.

Acetaminophen reduces activity in the COX pathways, even though it doesn’t bind to any receptors there. Although acetaminophen is well-tolerated, some people report adverse effects, such as nausea, vomiting, and constipation, when taking the medication intravenously.


Hydrocodone is a synthetic opioid that binds to and activates mu-opioid receptors in the central nervous system. This action produces a cough-suppressing (antitussive) and pain-relieving effect. Unfortunately, this action triggers euphoria, a highly sought-after effect by those who abuse hydrocodone.

What Are the Side Effects of M365 Pills?

Medications containing hydrocodone cause side effects. Some are manageable, but a few may indicate a serious reaction. Anyone experiencing serious side effects should seek emergency medical treatment immediately.

Commonly experienced side effects include:

  • Constipation
  • Drowsiness
  • Lightheadedness
  • Brain fog (difficulty thinking)
  • Anxiety
  • Rash
  • Itching
  • Dry throat
  • Difficulty urinating
  • Narrow pupils
  • Mood swings

Serious side effects include, but are not limited to:

  • Labored breathing
  • Erectile dysfunction
  • Irregular menstrual periods
  • Decreased sex drive
  • Vomiting
  • Loss of appetite
  • Weakness
  • Dizziness
  • Agitation
  • Hallucinations
  • Fever
  • Sweating
  • Confusion
  • Rapid heart rate
  • Shivering
  • Muscle stiffness
  • Involuntary twitches
  • Loss of coordination
  • Diarrhea

After treatment for serious side effects, reach out to the FDA and report the symptoms. They advise calling the Food and Drug Administration’s MedWatch Adverse Event Reporting program at 1-800-332-1088.

An allergic reaction to hydrocodone and acetaminophen could cause anaphylaxis. This dangerous allergic reaction causes hives, swelling, and difficulty breathing. You must receive treatment for anaphylaxis immediately to prevent permanent organ damage, anaphylactic shock, and death.

If you’re worried that you or a loved one is struggling with addiction, reach out for compassionate help at (855) 430-9439. Zinnia Health provides respectful care for individuals dealing with opioid and other addictions. Contact us today to learn more.

What Are The Dangers of M365 White Oval Pills?

Taking too much M365 can lead to addiction and overdose. Both conditions require professional care in a medical setting. Once addiction occurs, withdrawal symptoms increase the likelihood of an overdose, which can be deadly.

M365 Addiction

According to Stat Pearls, hydrocodone is one of the most commonly prescribed pain medications and one of the most abused by patients. This is due to it being an opioid. For this reason, the DEA lists hydrocodone combination medications as Schedule II controlled substances.

According to the National Cancer Institute, the opioid in M365 is hydrocodone, which comes from codeine. Codeine binds to opioid receptors in the central nervous system (CNS), also known as the brain’s “reward center.” Once they’re activated, it triggers the release of feel-good chemicals called endorphins.

It only takes a few days to develop a tolerance to opioids like hydrocodone, and the withdrawal symptoms are severe. To date, more than 3 million U.S. citizens suffer from or have suffered from an opioid use disorder (OUD).

The best way to avoid addiction to m365 white pills is to use the medication as directed. For example, do not take more if the medication doesn’t relieve enough pain. Instead, tell your physician so they can adjust the prescription.

M365 Overdose

M365 contains acetaminophen – a drug associated with liver failure when the dose exceeds 4,000 milligrams per day from any source or multiple sources, including over-the-counter pain relievers and cold or allergy medicines. This condition is called hepatoxicity. Even with prompt treatment, hepatoxicity can lead to a liver transplant or death, as the Daily Med points out.

According to the National Libraries of Medicine, most cases of acetaminophen-related hepatoxicity come from intentional overdose or suicide attempts.

Symptoms of acetaminophen overdose include:

  • Nausea
  • Vomiting
  • Loss of appetite
  • Sweating
  • Extreme fatigue
  • Unusual bleeding
  • Unexplained bruising
  • Yellowing of eyes or skin (jaundice)
  • Flu-like symptoms

In addition to acetaminophen, M365 contains the prescription drug opioid hydrocodone. According to the Substance Abuse and Mental Health Services Administration (SAMHSA), opioid overdoses occur when people take more medication than prescribed. This includes crushing or chewing the pills, which causes a rapid delivery of the drug.

It’s important to call 911 immediately for help if you suspect a hydrocodone overdose.

Symptoms of hydrocodone toxicity include:

  • CNS depression (difficulty breathing)
  • Bradycardia (slow heart rate)
  • Clammy skin
  • Hypotension
  • Miosis
  • Loss of consciousness
  • Fluid in the lungs
  • Aspiration pneumonitis

Hydrocodone toxicity can lead to CNS depression, leading to a deadly drop in blood pressure, a dangerously low heart rate, and labored breathing. Treatment for hydrocodone toxicity includes using an opioid antagonist medication like Naloxone.

M365 Withdrawal

The symptoms of M365 white pill withdrawal come from opioid addiction. The National Library of Medicine’s National Center for Biotechnology Information defines opioid withdrawal as a life-threatening condition resulting from opioid dependence.

Signs and symptoms of opioid withdrawal include:

  • Lacrimation (continuous eye-watering)
  • Goosebumps
  • Diarrhea
  • Nausea
  • Vomiting
  • Myalgia (muscle pain)
  • Dilated pupils
  • Sensitivity to light (photophobia)
  • Insomnia
  • Autonomic hyperactivity: fast heartbeat (tachycardia), fast breathing (tachypnea), sweating, high blood pressure (hypertension), fever, and yawning

Medical professionals use the COWS (Clinical Opioid Withdrawal Scale) assessment test to determine the severity of withdrawal symptoms. Anyone scoring 25 or greater on this assessment is experiencing moderate to severe withdrawal.

When a person experiences opioid withdrawal symptoms, they often return to the drug to relieve the discomfort. Medications like buprenorphine, loperamide, promethazine, ibuprofen, and clonidine are offered during detox to reduce these symptoms and discourage people from further abusing hydrocodone.

Getting Help for M365 Pill Addiction

Opioid addiction can stem from untreated mental health issues. In an NIH article titled “When Addiction and Mental Illness Collide,” experts highlight the unmistakable connection between untreated mental health conditions, such as depression, and an increased risk of opioid use disorder.

In this article, the authors state that those who receive treatment for both conditions simultaneously (collaborative care) are more likely to avoid overdose and get better. Collaborative care in an inpatient drug rehab provides detoxification, medication, counseling, and after-care tools to help the patient recover.

This includes prescription pharmaceuticals and psychological treatments for bipolar disorder, PTSD, anxiety disorder, personality disorders, schizophrenia, and depression.

If you or a loved one experience withdrawal symptoms when trying to stop m365 or often use more than recommended, you may be addicted. Stopping on your own isn’t recommended since it can be dangerous. Instead, seek help from a professional drug rehab to help you stop safely and effectively.

Overcome addiction with the compassionate care that Zinnia Health is known for. We provide a range of scientifically proven treatment methods, such as 12-step, medication-assisted treatment, and cognitive behavioral therapy, at our fully-accredited facilities.

Contact us at (855) 430-9439 to schedule a no-obligation, free consultation with one of our intake specialists today. We are here to help you turn your life around.

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